Patent Number: 7,612,080

Title: GTPase inhibitors and use thereof for controlling platelet hyperactivity

Abstract: The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

Inventors: Zheng; Yi (Cincinnati, OH), Akbar; Huzoor (Athens, OH), Williams; David A. (Cincinnati, OH), Mazur; Wieslaw Adam (Mason, OH)

Assignee: Cincinnati Children's Hospital Medical Center

International Classification: A61K 31/506 (20060101)

Expiration Date: 1/03/02017