Patent Number: 7,612,093

Title: Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy

Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

Inventors: Jacob; Gary S. (Creve Coeur, MO), Block; Timothy M. (Jenkintown, PA), Dwek; Raymond A. (North Hinksey, GB)

Assignee: United Therapeutics Corporation

International Classification: A61K 31/445 (20060101); A61K 31/505 (20060101); A61K 31/675 (20060101)

Expiration Date: 1/03/02017