Patent Number: 7,612,170

Title: Co-stimulatory polypeptides

Abstract: The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.

Inventors: Punnonen; Juha (Belmont, CA), Lazetic; Alexandra L. L. (San Jose, CA), Leong; Steven R. (Berkeley, CA), Chang; Jean Chia-Chun (Los Gatos, CA)

Assignee: Maxygen, Inc.

International Classification: C07K 14/705 (20060101); A61K 38/16 (20060101); C07K 16/46 (20060101)

Expiration Date: 1/03/02017