Patent Number: 7,612,174

Title: Scavenger receptor

Abstract: Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper .beta.-lipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypo .alpha.-lipoproteinemia, transplantation, atherectomy, post angiogenic restenosis, bacterial infections; in the diagnostic, prophylactic and therapeutic methods thereof; and in the development of reagents and drugs for the same. The novel scavenger receptors include proteins comprising an amino acid sequence set out in SEQ ID NO: 2, 4 or 24 or proteins having equivalent properties to the same, or derivatives or fragments thereof as well as isolated polynucleotides comprising a nucleotide sequence encoding these proteins, and related molecules such as antibodies, antagonists and the like. Also disclosed are methods for the treatment using the same.

Inventors: Wakamiya; Nobutaka (Hokkaido, JP)

Assignee: Fuso Pharmaceutical Industries, Ltd.

International Classification: C07K 14/705 (20060101); A61K 39/00 (20060101); C12N 15/06 (20060101); G01N 33/53 (20060101)

Expiration Date: 1/03/02017