Patent Number: 7,709,253

Title: Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists

Abstract: Briefly described, embodiments of this disclosure include ligand-regulable transactivation systems, methods of producing ligand-regulable transactivation systems, methods of using ligand-regulable transactivation systems, reporter polynucleotides, method of producing reporter polynucleotides, activator fusion proteins, methods of producing activator fusion proteins, methods of regulating gene expression in vitro and in vivo for gene therapy, methods of screening estrogen receptor modulators with therapeutic treatments (e.g., anticancer, antiosteoporosis, and hormone replacement treatments), method of screening compounds (e.g., drugs and environmental pollutants) for the estrogenic effect, methods of evaluating the estrogen receptor pathway under different pathological conditions are provided, and the like.

Inventors: Gambhir; Sanjiv S. (Portola Valley, CA), Paulmurugan; Ramasamy (Mountain View, CA)

Assignee: The Board of Trustees of the Leland Stanford Junior University

International Classification: C12N 5/00 (20060101); C07H 21/04 (20060101); C07K 14/00 (20060101); C12P 19/34 (20060101); C12N 15/00 (20060101)

Expiration Date: 5/04/12018