Patent Number: 7,709,270

Title: Vascular endothelial growth factor C (VEGF-C) protein diagnostic

Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.

Inventors: Alitalo; Kari (Helsinki, FI), Joukov; Vladimir (Boston, MA)

Assignee: Vegenics Ltd.

International Classification: C07K 16/18 (20060101); C07K 16/22 (20060101)

Expiration Date: 5/04/12018