Patent Number: 7,709,442

Title: In vivo synthesis of connective tissues

Abstract: The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible scaffold such as gelatin and placed between two other biocompatible scaffolds such as collagen sponges soaked with a collagenic amount of a member of the TGF-.beta. family of proteins. This composition is then implanted in a host to produce cranial sutures, periodontal ligament or other fibrous tissue structures in vivo.

Inventors: Mao; Jeremy Jian (Closter, NJ)

Assignee: The Trustees of Columbia University in the City of New York

International Classification: A61K 45/00 (20060101); A61F 2/02 (20060101); A61F 2/08 (20060101); A61K 47/36 (20060101); A61K 38/18 (20060101); A61K 38/19 (20060101)

Expiration Date: 5/04/12018