Patent Number: 7,709,445

Title: Colloidal suspension of nanoparticles based on an amphiphilic copolymer

Abstract: An aqueous suspension, stable in physiological medium, of nanoparticles for delivering active principles such as insulin. The delivery particles are based on a three-block copolymer: polyethylene glycol/hydrophilic polyaminoacid/hydrophobic polyaminoacid. These three-block copolymers can be associated with an active principle without denaturing it, and perform a controlled and long-term release of the active principle in vivo, and thus provide the active principle with a very prolonged release. Also disclosed is a powder form solid from which are derived the delivery particles, the preparation of the powder-form solid, a suspension of delivery particles based on the three-block copolymer, and pharmaceutical specialties obtainable from the delivery particles filled with active principle.

Inventors: Soula; Gerard (Meyzieu, FR), Bryson; Nathan (Millery, FR)

Assignee: Flamel Technologies

International Classification: A61K 38/02 (20060101); A61K 9/10 (20060101)

Expiration Date: 5/04/12018