Patent Number: 7,709,465

Title: Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers

Abstract: Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.

Inventors: Hergenrother; Paul J. (Champaign, IL), Nesterenko; Vitaliy (Rantoul, IL), Putt; Karson S. (Champaign, IL), Palchaudhuri; Rahul (Champaign, IL)

Assignee: The Board of Trustees of the University of Illinois

International Classification: A61K 31/66 (20060101); C07F 9/02 (20060101)

Expiration Date: 5/04/12018