Patent Number: 7,709,510

Title: Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators

Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R.sub.1, R.sub.2, R.sub.6, and R.sub.7 are defined herein. ##STR00001##

Inventors: Arrhenius; Thomas (Del Mar, CA), Cheng; Jie Fei (Carlsbad, CA), Wilson; Mark E. (Ramona, CA), Serafimov; Rossy (Metz, FR), Nadzan; Alex M. (Encinitas, CA), Lopaschuk; Gary D. (Edmonton, CA), Dyck; Jason R. (Sherwood Park, CA)

Assignee: Chugai Seiyaku Kabushiki Kaisha

International Classification: A61K 31/425 (20060101); C07D 277/00 (20060101); C07D 277/62 (20060101)

Expiration Date: 5/04/12018