Patent Number: 7,709,607

Title: Adiponectin variants

Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.

Inventors: Zalevsky; Jonathan (Riverside, CA), Nguyen; Duc-Hanh Thi (Sylmar, CA), Moore; Gregory L. (Monrovia, CA), Ezhevsky; Sergei A. (San Diego, CA), Desjarlais; John R. (Pasadena, CA), Chirino; Arthur J. (Camarillo, CA), Cash; Darian (Los Angeles, CA), Bernett; Matthew J. (Monrovia, CA)

Assignee: Xencor, Inc.

International Classification: C07K 1/00 (20060101); A61K 38/24 (20060101); A61K 38/27 (20060101); C07K 14/00 (20060101); C07K 16/00 (20060101); C07K 17/00 (20060101)

Expiration Date: 5/04/12018