Patent Number: 7,709,625

Title: Methods and compositions for bone marrow stem cell-derived macrophage delivery of genes for gene therapy

Abstract: The present invention provides an isolated nucleic acid comprising a promoter operably linked to a nucleic acid encoding a peptide or protein and/or an RNA (e.g., antisense or ribozyme), wherein the promoter comprises elements that can include, but are not limited to, a) a myeloid specific promoter element comprising a core sequence GAGGAA; b) a myeloid specific promoter element comprising a core sequence AAGGAGAAG; c) a myeloid specific promoter element comprising a core sequence TTTCCAAA; d) a myeloid specific promoter element comprising a core sequence TGTGGTTGC; e) a myeloid specific promoter element comprising a core sequence TGAGTCA; f) a myeloid associated promoter element comprising a core sequence CCGCCC; and g) any combination of (a), (b), (c), (d), (e) and/or (f), any combination of multiples of (a), (b), (c), (d), (e) and/or (f), in any order and/or in any orientation (forward or reverse).

Inventors: Li; Senlin (San Antonio, TX), Clark; Robert A. (San Antonio, TX)

Assignee: The Board of Regents of the University of Texas

International Classification: C07H 21/04 (20060101); C12N 15/00 (20060101); C12N 15/63 (20060101); C12N 5/00 (20060101); C12Q 1/68 (20060101)

Expiration Date: 5/04/12018