Patent Number: 7,709,642

Title: Spirohydantoin compounds and methods for the modulation of chemokine receptor activity

Abstract: Novel compounds represented by formula (I): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined herein, and pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.

Inventors: Chan Chun Kong; Laval (Kirkland, CA), Moinet; Christophe (Montreal, CA), Vaillancourt; Louis (Mascouche, CA), Bubenik; Monica (Montreal, CA)

Assignee: Virochem Pharma, Inc.

International Classification: A01N 43/42 (20060101); A61K 31/44 (20060101); C07D 401/00 (20060101); C07D 451/00 (20060101); C07D 453/00 (20060101); C07D 455/00 (20060101); C07D 471/00 (20060101)

Expiration Date: 5/04/12018