Patent Number: 7,709,644

Title: Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane

Abstract: The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.

Inventors: Diehl; Herbert (Leverkusen, DE), Krebs; Andreas (Odenthal, DE), Krebs, legal representative; Elvira (Odenthal, DE), Lange; Walter (Odenthal, DE), Paul; Hanns-Ingolf (Leverkusen, DE), Seidel; Dietrich (Wuppertal, DE), Grosser; Rolf (Leverkusen, DE), Reichelt; Tobias (Koln, DE)

Assignee: LANXESS Deutschland GmbH

International Classification: C07D 487/04 (20060101)

Expiration Date: 5/04/12018