Patent Number: 7,709,695

Title: Transgenic mouse expressing arctic mutation E693G

Abstract: A transgenic non-human animal expressing at least one transgene including a DNA sequence encoding a heterologous Amyloid Precursor Protein (APP) including at least the Arctic mutation (E693G) and a further AD (Alzheimer's disease) pathogenic mutation or a further transgene affecting AD pathogenesis, which results in increased amounts of intracellular soluble A aggregates, including A peptides. The method of producing the transgenic animal, and methods of screening for therapeutic or diagnostic agents useful in treatment or diagnosis of Alzheimer's disease are also disclosed.

Inventors: Nilsson; Lars (Uppsala, SE), Lannfelt; Lars (Uppsala, SE), Gellerfors; Par (Lidingo, SE)

Assignee: BioArctic Neuroscience AB

International Classification: G01N 33/00 (20060101); A01K 67/033 (20060101)

Expiration Date: 5/04/12018