Patent Number: 7,713,522

Title: Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases

Abstract: The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vivo using a gutless adenovirus vector. Another aspect of the present invention is to provide a gutless adenovirus vector carrying a transgene, such as a gene encoding TM protein or its variant.

Inventors: Sehgal; Lakshman R. (Monarch Beach, CA), Wong; Jonathan (Palo Alto, CA)

Assignee: BioVec, LLC

International Classification: A01N 63/00 (20060101); A61K 31/715 (20060101); C07H 21/04 (20060101); C12N 15/86 (20060101)

Expiration Date: 5/11/12018