Patent Number: 7,713,915

Title: Cytotoxic heteromeric protein combinatorial libraries

Abstract: A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit of a wild type heteromeric cytotoxic protein to create a library of microorganism clones producing mutant proteins which are then screened for their ability to specifically bind to and kill a target cell.

Inventors: Gariepy; Jean (Toronto, CA), Bray; Mark Robert (Toronto, CA)

Assignee: Molecular Templates, Inc.

International Classification: C40B 30/04 (20060101); G01N 33/53 (20060101)

Expiration Date: 5/11/12018