Patent Number: 7,714,008

Title: Heterocyclic GPR40 modulators

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: ##STR00001## where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Inventors: Beck; Hilary (San Carlos, CA), Dransfield; Paul (San Francisco, CA), Fu; Zice (Foster City, CA), Houze; Jonathan B. (San Mateo, CA), Jiao; XianYun (Belmont, CA), Kohn; Todd J. (San Mateo, CA), Lai; SuJen (Burlingame, CA), Liu; Jinqian (Palo Alto, CA), Liu; Jiwen (Foster City, CA), Ma; Zhihua (San Mateo, CA), Medina; Julio C. (San Carlos, CA), Schmitt; Michael J. (Oakland, CA), Sharma; Rajiv (Fremont, CA), Shen; Wang (San Mateo, CA), Vimolratana; Marc (San Mateo, CA), Wang; Yingcai (Fremont, CA), Wang; Zhongyu (San Mateo, CA)

Assignee: Amgen Inc.

International Classification: A61K 31/192 (20060101); A61K 31/422 (20060101); C07C 59/11 (20060101); C07D 261/06 (20060101)

Expiration Date: 5/11/12018