Patent Number: 7,714,100

Title: Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease

Abstract: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

Inventors: Cohen; Yossi (Banstead, GB), Diber; Alexander (Rishon-LeZion, IL), Toporik; Amir (Azur, IL), Pollock; Sarah (Tel-Aviv, IL), Levine; Zurit (Herzlia, IL), Ayalon-Soffer; Michal (Ramat-HaSharon, IL), Cojocaru; Gad S. (Ramat-HaSharon, IL), Novik; Amit (Beit-HaSharon, IL), Kol; Guy (Givat Shmuel, IL), Sella-Tavor; Osnat (Kfar Kish, IL), Walach; Shira (Hod-HaSharon, IL), Sameah-Greenwald; Shirley (Kfar-Saba, IL), Dahary; Dvir (Tel-Aviv, IL), Shemesh; Ronen (Modiln, IL)

Assignee: Compugen LTD

International Classification: A61K 38/00 (20060101)

Expiration Date: 5/11/12018