Patent Number: 7,714,108

Title: Mammalian tumor susceptibility gene products and their uses

Abstract: The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein.

Inventors: Li; Limin (Rockville, MD), Cohen; Stanley N. (Portola Valley, CA)

Assignee: The Board of Trustees of the Leland Stanford Junior University

International Classification: C07K 16/00 (20060101); A61K 39/395 (20060101)

Expiration Date: 5/11/12018