Patent Number: 7,714,141

Title: Processes for production of optically active PPAR-activating compounds and intermediates for production thereof

Abstract: The invention provides a process for producing an optically active butyric acid compound and a production intermediate therefore at high yield and high purity. The present invention provides a process for producing Compound (6), including reacting Compound (1) with optically active 2-trifluoromethanesulfonyloxybutyrolactone (2a) in the presence of a base or reacting optically active 2-hydroxybutyrolactone (2b) under Mitsunobu reaction conditions, to thereby form Compound (3); reacting Compound (3) with an alcohol and a halogenating agent, to thereby form Compound (4); dehalogenating Compound (4), to thereby form Compound (5); and de-esterifying Compound (5). ##STR00001##

Inventors: Yamazaki; Yukiyoshi (Higashimurayama, JP), Araki; Takaaki (Higashimurayama, JP), Koura; Minoru (Kawagoe, JP), Shibuya; Kimiyuki (Tokorozawa, JP)

Assignee: Kowa Co., Ltd.

International Classification: C07D 263/58 (20060101); C07D 235/30 (20060101); C07D 277/82 (20060101)

Expiration Date: 5/11/12018