Patent Number: 7,731,961

Title: Methods of increasing muscle mass or muscle strength using antibody inhibitors of GDF-8

Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.

Inventors: Aghajanian; Jane (Belgrade, ME), Dunham, legal representative; William J. (Belgrade, ME), Wolfman; Neil M. (Dover, MA), O'Hara; Denise (Reading, MA), Davies; Monique V. (Harpswell, MA), Veldman; Geertruida M. (Sudbury, MA), Bridges; Kristie Grove (Maynard, MA), Whittemore; Lisa-Anne (East Walpole, MA), Khurana; Tejvir S. (Narberth, PA), Bouxsein; Mary L. (Brookline, MA)

Assignee: Wyeth

International Classification: A61K 39/395 (20060101); C07K 16/00 (20060101)

Expiration Date: 2022-06-08 0:00:00