Patent Number: 7,732,420

Title: Combinations of transfection lipids exhibiting increased transfection efficiencies

Abstract: The present invention provides optimized transfection reagents comprising mixtures of cationiclipoids. In particular, the present invention provides DNA delivery vehicles based on identifying the optimal hydrophobicity of novel cationic phospholipid derivatives that, alone or in combination, form complexes with DNA (lipoplexes) and exhibit enhanced transfection activity.

Inventors: MacDonald; Robert C. (Evanston, IL), Wang; Li (Evanston, IL)

Assignee: Northwestern University

International Classification: A01N 43/04 (20060101); A61K 31/70 (20060101); C12N 5/00 (20060101); C12N 5/02 (20060101); G01N 33/92 (20060101)

Expiration Date: 2022-06-08 0:00:00