Patent Number: 7,785,588

Title: Anti-neurturin receptor-A antibody compositions comprising cytokines or neurotrophic factors

Abstract: NTNR.alpha., NTNR.alpha. extracellular domain (ECD), NTNR.alpha. variants, chimeric NTNR.alpha. (e.g., NTNR.alpha. immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR.alpha.-ligands, for example NTN, by providing NTNR.alpha. to the cell.

Inventors: Klein; Robert D. (Palo Alto, CA), Rosenthal; Arnon (Burlingame, CA), Hynes; Mary A. (San Mateo, CA)

Assignee: Genentech, Inc.

International Classification: A61K 39/395 (20060101); C07K 14/00 (20060101); C07K 16/00 (20060101); C12P 21/08 (20060101); A61K 39/00 (20060101); C07K 4/00 (20060101); C07K 7/00 (20060101); C07K 2/00 (20060101)

Expiration Date: 8/31/12018