Patent Number: 7,785,593

Title: Antibody (11C7) anti nogo a and its pharmaceutical use

Abstract: This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or human NogoA_623-640 with a dissociation constant <1000 nM; polynucleotides encoding such a binding molecule; an expression vector comprising such polynucleotides; the use of such a binding molecule in the treatment of nerve repair, a pharmaceutical composition comprising such a binding molecule; and to a method of treatment of diseases associated with nerve repair.

Inventors: Barske; Carmen (Loerrach, DE), Mir; Anis Khusro (Bartenheim, FR), Oertle; Thomas (Gerra/Gambarogno, CH), Schnell; Lisa (Zurich, CH), Schwab; Martin E. (Zurich, CH), Vitaliti; Alessandra (Bedigliora, CH), Zurini; Mauro (Binningen, CH)

Assignee: Novartis AG

International Classification: C07K 16/00 (20060101); A61K 39/00 (20060101); A61K 39/395 (20060101)

Expiration Date: 8/31/12018