Patent Number: 7,785,595

Title: Stabilized anti-hepatitis B (HBV) antibody formulations

Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.

Inventors: Dagan; Shlomo (Nes Ziona, IL), Eren; Rachel (Moshav Netaim, IL), Misra; Hemant Kumar (Shrewsbury, MA), Gowan, Jr.; Walter G. (Pelham, AL), O'Connor; Sandra (Mont Vernan, NH)

Assignee: Yeda Research and Development Company Limited

International Classification: A61K 39/42 (20060101); A61K 39/00 (20060101); A61K 39/29 (20060101); A61K 48/00 (20060101)

Expiration Date: 8/31/12018