Patent Number: 7,785,597

Title: VMP-like sequences of pathogenic Borrelia

Abstract: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

Inventors: Norris; Steven J. (Houston, TX), Zhang; Jing-Ren (Delmar, NY), Hardham; John M. (Gales Ferry, CT), Howell; Jerrilyn K. (Houston, TX), Barbour; Alan G. (Newport Beach, CA), Weinstock; George M. (Houston, TX)

Assignee: Board of Regents, The University of Texas System

International Classification: A61K 39/00 (20060101); A61K 39/02 (20060101); A61K 39/38 (20060101)

Expiration Date: 8/31/12018