Patent Number: 7,785,805

Title: MAN2As as modifiers of the IGFR pathway and methods of use

Abstract: Human MAN2A genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of MAN2A are provided.

Inventors: Friedman; Lori (San Carlos, CA), Francis-Lang; Helen (San Francisco, CA), Parks; Annette L. (Newton, MA), Shaw; Kenneth James (Brisbane, CA), Zhang; HaiGuang (El Sobrante, CA), Heuer; Timothy S. (El Granada, CA)

Assignee: Exelixis, Inc.

International Classification: G01N 33/53 (20060101)

Expiration Date: 8/31/12018