Patent Number: 7,785,808

Title: Treatment of inflammation using .alpha.7 receptor-binding cholinergic agonists

Abstract: A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an .alpha.7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an .alpha.7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein. ##STR00001##

Inventors: Tracey; Kevin J. (Old Greenwich, CT), Wang; Hong (Havertown, PA)

Assignee: The Feinstein Institute for Medical Research

International Classification: G01N 33/567 (20060101); G01N 33/53 (20060101)

Expiration Date: 8/31/12018