Patent Number: 7,785,811

Title: BPC-1: a secreted brain-specific protein expressed and secreted by prostate and bladder cancer cells

Abstract: Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-1 is only expressed in certain tissues of the brain. However, BPC-1 is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC-1 includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC-1 is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-1 also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.

Inventors: Afar; Daniel E. (Pacific Palisades, CA), Hubert; Rene S. (Los Angeles, CA), Leong; Kahan (Playa Del Rey, CA), Raitano; Arthur B. (Los Angeles, CA), Saffran; Douglas (Encinitas, CA), Jakobovits; Aya (Beverly Hills, CA)

Assignee: Agensys, Inc.

International Classification: G01N 33/574 (20060101)

Expiration Date: 8/31/12018