Patent Number: 7,785,838

Title: Variants of mammalian prolactin, prolactin receptor antagonists, and methods of use

Abstract: Mammalian prolactin (PRL) variants having a mutation or set of mutations within the 14 N-terminal amino acids that prevent the formation of a disulfide bridge between Cys.sub.4 and Cys.sub.11 and, a sterically hindering mutation or set of mutations within binding site 2 of PRL. These variants are useful as antagonists of mammalian prolactin receptors (PRLR), more particularly of human prolactin receptor (hPRLR).

Inventors: Goffin; Vincent (Orgerus, FR), Bernichtein; Sophie (Aubervilliers, FR), Kelly; Paul A. (Paris, FR)

Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)

International Classification: A61K 38/18 (20060101); C12N 15/16 (20060101); C12N 15/63 (20060101); C12N 1/21 (20060101); C07K 14/475 (20060101)

Expiration Date: 8/31/12018