Patent Number: 7,785,870

Title: Cell-specific expression/replication vector

Abstract: The present invention provides a cell-specific expression/replication vector, and a method of treatment comprising introducing a cell-specific expression/replication vector into specific cells such as malignant tumors in order to selectively disrupt the specific cells. A vector according to the invention is constructed by: obtaining a transcriptional initiation regulatory region of human calponin gene that is specifically expressed in smooth muscle cell; linking the above region upstream to a replication-related gene of a virus such as ICP4 and the like; linking DNA that encodes a protein such as suppressive factor for tumor angiogenesis or apoptosis-related factors and the like via IRES to the replication-related gene of the virus; and integrating a thymidine kinase gene in an intact state into the viral DNA.

Inventors: Takahashi; Katsuhito (Ikeda, JP), Yamamura; Hisako (Ikoma, JP)

Assignee: Japan Science and Technology Agency

International Classification: C12N 15/00 (20060101); A61K 31/70 (20060101)

Expiration Date: 8/31/12018