Patent Number: 7,785,887

Title: Adenovirus E1B-55K single amino acid mutants and methods of use

Abstract: Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.

Inventors: Shen; Yuqiao (Richmond, CA), Nye; Julie (Berkeley, CA), Hermiston; Terry (Corte Madera, CA)

Assignee: Onyx Pharmaceuticals, Inc.

International Classification: C12N 15/861 (20060101); A01N 63/00 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101)

Expiration Date: 8/31/12018