Patent Number: 7,786,071

Title: Pon polypeptides polynucleotides encoding same and compositions and methods utilizing same

Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.

Inventors: Tawfik; Dan S. (Jerusalem, IL), Aharoni; Amir (Tel Aviv, IL), Gaydukov; Leonid (Rehovot, IL), Sussman; Joel L. (Rehovot, IL), Silman; Israel (Rehovot, IL)

Assignee: Yeda Research And Development Co. Ltd.

International Classification: C12N 9/00 (20060101); C12N 9/14 (20060101); C12N 9/16 (20060101)

Expiration Date: 8/31/12018