Patent Number: 7,786,131

Title: Pyrimido[5,4-d]pyrimidines derivatives as irreversible inhibitors of tyrosine kinases

Abstract: The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, ##STR00001## wherein Q is ##STR00002## and X, E.sup.1, E.sup.2, E.sup.3, R.sup.6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.

Inventors: Bridges; Alexander James (Saline, MI), Denny; William Alexander (Auckland, NZ), Dobrusin; Ellen Myra (Ann Arbor, MI), Doherty; Annette Marian (Paris, FR), Fry; David William (Ypsilanti, MI), McNamara; Dennis Joseph (Ann Arbor, MI), Showalter; Howard Daniel Hollis (Ann Arbor, MI), Smaill; Jeffrey B. (Auckland, NZ), Zhou; Hairong (Ann Arbor, MI)

Assignee: Warner-Lambert Company

International Classification: C07D 487/04 (20060101); A61K 31/519 (20060101); C07D 239/94 (20060101); C07D 413/12 (20060101); C07D 413/14 (20060101); A61P 17/06 (20060101); A61P 35/00 (20060101); C07D 491/04 (20060101)

Expiration Date: 8/31/12018