Patent Number: 7,786,135

Title: Substituted pyrroline kinase inhibitors

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

Inventors: Zhang; Han-Cheng (Lansdale, PA), Kuo; Gee-Hong (Scotch Plains, NJ), Maryanoff; Bruce E. (Forest Grove, PA), Ye; Hong (Lansdale, PA), O'Neill; David (Flemington, NJ), Shen; Lan (Clinton, NJ), Demarest; Keith (Flemington, NJ), Conway; Bruce R. (Doylestown, PA), McComsey; David F. (Warminster, PA)

Assignee: Janssen Pharmaceutica, N.V.

International Classification: A61K 31/437 (20060101); A61K 31/4353 (20060101); A61K 31/407 (20060101)

Expiration Date: 8/31/12018