Patent Number: 7,786,145

Title: Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors

Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity. ##STR00001##

Inventors: Cheng; Jie Fei (Carlsbad, CA), Liu; Bin (Los Angeles, CA), Arrhenius; Thomas (Del Mar, CA), Wilson; Mark E. (Ramona, CA), Nadzan; Alex M. (Encinitas, CA), Lopaschuk; Gary D. (Edmonton, CA), Dyck; Jason R. (Sherwood Park, CA), Serafimov; Rossy (Metz, FR)

Assignee: Chugai Seiyaku Kabushiki Kaisha

International Classification: A61K 31/4406 (20060101); C07D 207/14 (20060101); C07D 277/72 (20060101); C07D 417/12 (20060101); A61K 31/428 (20060101); A61K 31/4025 (20060101)

Expiration Date: 8/31/12018