Patent Number: 7,786,170

Title: Histone deacetylase inhibitor enhancement of trail-induced apoptosis

Abstract: Due to the poor long-term clinical outcome in the adult patients with several forms of acute leukemia novel treatment strategies are needed to overcome resistance and sensitize the leukemia blasts to the extrinsic and intrinsic pathway of apoptosis. Treatment with LAQ824 and Apo-2L/TRAIL alone has been recognized to induce apoptosis of leukemia blasts but intrinsic mechanisms of resistance limit the antileukemia activity of either agent when administered alone. The inventive method overcomes the resistance to current apoptosis inducing treatments demonstrated by AML and CML-BC cells by concomitantly administering Apo-2L/TRAIL with the histone deacetylase inhibitor LAQ824.

Inventors: Bhalla; Kapil N. (Tampa, FL)

Assignee: University of South Florida

International Classification: A61K 31/19 (20060101); A61K 38/00 (20060101)

Expiration Date: 8/31/12018