Patent Number: 7,786,259

Title: Attachment and elaboration strategies for inverse peptide synthesis

Abstract: The present invention provides a process for preparing an immobilized peptide derivative of formula (Vb): ##STR00001## comprising reacting a functionalized solid support comprising Sub-L wherein Sub is a solid support and L is a cleavable linker, with H--[NH--A--C(O)]--O(tBu), then reacting the immobilized product with compound of the formula RHN--A--C(O)OH, wherein the RHN--A--C(O) group is the residue of a N-protected .alpha.-amino acid, in the presence of a coupling agent, to yield an immobilized peptide derivative of the formula (Vb).

Inventors: Gutheil; William G. (Kansas City, MO)

Assignee: The Curators of the University of Missouri

International Classification: C07K 1/04 (20060101)

Expiration Date: 8/31/12018