Patent Number: 7,786,291

Title: Compositions and methods for short interfering nucleic acid inhibition of Na.sub.v1.8

Abstract: The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Na.sub.v1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.

Inventors: Goregaoker; Sameer (Ithaca, NY), Hunter; John C. (Warren, NJ), Priestley; Tony (Bridgewater, NJ)

Assignee: Schering Corporation

International Classification: C07H 21/02 (20060101); C12P 19/34 (20060101); C12Q 1/68 (20060101); C07H 21/04 (20060101)

Expiration Date: 8/31/12018