Patent Number: 7,820,156

Title: Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine

Abstract: The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.

Inventors: Dinarello; Charles A (Boulder, CO), Kim; Soo-Hyun (Aurora, CO), Bufler; Philip (Grafelfing, DE)

Assignee: Ares Trading S.A.

International Classification: A61K 38/00 (20060101); A61K 45/00 (20060101)

Expiration Date: 2018-10-26 0:00:00