Patent Number: 7,820,158

Title: Ligand-coupled initiator polymers and methods of use

Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic .beta. cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

Inventors: Chudzik; Stephen J. (St. Paul, MN), Swan; Dale G. (St. Louis Park, MN)

Assignee: SurModics, Inc.

International Classification: A61K 9/50 (20060101); C12N 5/00 (20060101); C12N 11/04 (20060101)

Expiration Date: 2018-10-26 0:00:00