Patent Number: 7,820,172

Title: Laminin-derived multi-domain peptides

Abstract: Multi-domain peptides including a heparin-binding peptide sequence covalently linked to a linker sequence, which linker sequence is covalently linked to a trifunctional amino acid residue forming a branch with two arms, with substantially similar (homodimeric) cellular attachment peptide sequences covalently linked, directly or through an intermediate, to each branch arm, where the sequences are cell binding analogs of or derived from laminin or a portion of laminin. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.

Inventors: Zamora; Paul O. (Gaithersburg, MD), Takahashi; Kazuyuki (Germantown, MD), Lin; Xinhua (Plainview, NY)

Assignee: BioSurface Engineering Technologies, Inc.

International Classification: A61K 38/04 (20060101); A61K 39/00 (20060101)

Expiration Date: 2018-10-26 0:00:00