Patent Number: 7,820,174

Title: T cell receptors and related materials and methods of use

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

Inventors: Wang; Qiong J. (Reston, VA), Hanada; Kenichi (Bethesda, MD), Yang; James C. (Silver Spring, MD)

Assignee: The United States of America as represented by the Department of Health and Human Services

International Classification: A61K 38/17 (20060101)

Expiration Date: 2018-10-26 0:00:00