Patent Number: 7,820,180

Title: Listeria-based and LLO-based vaccines

Abstract: This invention provides methods of treating and vaccinating against an antigen-expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strain expressing the antigen. The present invention also provides recombinant peptides comprising a listeriolysin (LLO) protein fragment fused to a Her-2 protein or fragment thereof, recombinant Listeria strains expressing a Her-2 protein, vaccines and immunogenic compositions comprising same, and methods of inducing an anti-Her-2 immune response and treating and vaccinating against a Her-2-expressing tumor, comprising same.

Inventors: Singh; Reshma (Philadelphia, PA), Paterson; Yvonne (Philadelphia, PA)

Assignee: The Trustees of the University of Pennsylvania

International Classification: A61K 39/02 (20060101); A61K 38/04 (20060101); A61K 38/16 (20060101)

Expiration Date: 2018-10-26 0:00:00