Patent Number: 7,820,631

Title: Anti-viral pyrimidine nucleoside analogues

Abstract: A nucleoside analogue compound is provided which has a six-membered aromatic ring system, the aromatic ring system being substituted in the para position with an unbranched unsubstituted alkyl or alkoxy moiety, wherein the alkyl or alkoxy moiety, in total, has from 3 to 8 carbon atoms. This compound shows anti-vira1 activity, for example with respect to varicella zoster virus and can thus be used in therapeutic methods for the prophylaxis and treatment of viral infections such as varicella zoster virus.

Inventors: McGuigan; Christopher (Cardiff, GB), Balzarini; Jan (Heverlee, BE)

Assignee: Rega Foundation

International Classification: A61K 31/7048 (20060101); A61K 31/517 (20060101); C07H 19/073 (20060101); C07H 19/09 (20060101); C07H 19/10 (20060101); C07H 19/14 (20060101); C07D 491/048 (20060101); C07H 19/06 (20060101); C07H 19/067 (20060101); A61K 31/7056 (20060101); A61K 31/7068 (20060101); A61K 31/519 (20060101); C07D 239/70 (20060101); C07D 495/04 (20060101); C07C 247/02 (20060101)

Expiration Date: 2018-10-26 0:00:00