Patent Number: 7,820,659

Title: Cyclohexylimidiazole lactam derivatives as inhibitors of 11-.beta.-hydroxysteroid dehydrogenase 1

Abstract: The present invention discloses novel compounds of Formula I: (I) having 11.beta.-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11.beta.-HSD type 1 activity. ##STR00001##

Inventors: Saeed; Ashraf (Westfield, IN), Wallace; Owen Brendan (Westfield, IN), Xu; Yanping (Noblesville, IN), Mabry; Thomas Edward (Indianapolis, IN), Guenther; Rebecca Lynn Rezac (Lonsdale, MN), Snyder; Nancy June (Lizton, IN)

Assignee: Eli Lilly and Company

International Classification: A61K 31/41 (20060101); A61K 31/42 (20060101); A61K 31/497 (20060101); A61K 31/505 (20060101); A61K 31/535 (20060101); C07D 211/32 (20060101); C07D 403/02 (20060101); C07D 413/14 (20060101); A61K 31/44 (20060101); A61K 31/445 (20060101)

Expiration Date: 2018-10-26 0:00:00