Patent Number: 7,820,667

Title: Methods of treating hypertension

Abstract: It is an object of the present invention to provide a therapeutic agent for effectively preventing or ameliorating diseases caused by dysfunction of NOS. The present invention provides a pharmaceutical composition for preventing and/or treating diseases associated with dysfunction of NOS, comprising as an effective ingredient, a compound of the formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or, taken together with each other, represent a single bond, while R.sup.3 represents --CH(OH)CH(OH)CH.sub.3, --CH(OCOCH.sub.3)CH(OCOCH.sub.3)CH.sub.3, --CH.sub.3, --CH.sub.2OH, or a phenyl group when R.sup.1 and R.sup.2 each represents a hydrogen atom, or --COCH(OH)CH.sub.3 when R.sup.1 and R.sup.2 together represent a single bond, or a pharmaceutically acceptable salt thereof.

Inventors: Ishihara; Takafumi (Osaka, JP), Kanayama; Yoshiharu (Osaka, JP), Okamura; Mikio (Osaka, JP), Yoshikawa; Junichi (Hyogo-ken, JP), Shintaku; Haruo (Osaka, JP)

Assignee: Daiichi Sankyo Company, Limited

International Classification: A61K 31/519 (20060101)

Expiration Date: 2018-10-26 0:00:00