Patent Number: 7,820,670

Title: 6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions

Abstract: Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.

Inventors: Chen; Hwang-Hsing (Fort Worth, TX), Rusinko; Andrew (Arlington, TX), Hellberg; Mark R. (Arlington, TX), Severns; Bryon S. (Arlington, TX), Henderson; Alan J. (Albany, NY), Guo; Cheng (Schenectady, NY), Hadden; Mark (Albany, NY)

Assignee: Alcon Research, Ltd.

International Classification: A61K 31/501 (20060101)

Expiration Date: 2018-10-26 0:00:00