Patent Number: 7,820,687

Title: Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by VLA-4

Abstract: Disclosed are compounds, which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a human or animal subject such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, Crohn's disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Inventors: Smith; Jenifer (South San Francisco, CA), Semko; Chris (Fremont, CA), Xu; Ying-Zi (Palo Alto, CA), Konradi; Andrei W. (Burlingame, CA)

Assignee: Elan Pharmaceuticals, Inc.

International Classification: A61K 31/506 (20060101); A61P 25/14 (20060101); A61P 19/02 (20060101); A61P 11/06 (20060101); A61P 1/06 (20060101); A61P 35/04 (20060101); C07D 403/12 (20060101); C07D 239/50 (20060101); A61P 37/06 (20060101)

Expiration Date: 2018-10-26 0:00:00